This is generally described as SQL vs NoSQL.

PropertyStructured DBsUnstructured DBs
StructureHelps with complex queries, but is hard to modify to fit new dataHelps with semi-structured data, and is easy to modify
ScalingDesigned with vertical scaling in mind (adding RAM, Storage, CPUs)Designed with horizontal scaling (sharding) in mind (adding more machines side by side)
CostRequires a lot of performanceCan adapt to any machine system, easy-going
SecurityThey are not designed to be as secure as unstructured databasesSince they are designed to be sharded, they were designed with security and self-healing in mind
Flexibility